In Poma's Lab we focus on developing novel computational strategies for the study of complex biological systems, exploring at the nanoscale how single molecular motions give rise to collective properties. This includes, for instance, changes in the biomechanical properties of large protein assemblies under varying physiological conditions. The group combines different theoretical tools and multiscale simulations to bridge the gap between length and time scales in macromolecular systems. The team is also part of the Martini open community and works toward a versatile GōMartini model for describing large conformational changes in biomolecular complexes. Our approach has been validated against all-atom MD simulations and, more recently, against single-molecule force spectroscopy (SMFS) experiments.