PomaLab is looking for 1 Postdoc

Join our multidisciplinary team working on the molecular mechanisms governing the transition of intrinsically disordered protein (IDP) condensates into amyloid-like fibrils, a process implicated in the early stages of neurodegenerative diseases. The project combines advanced computational modeling and experimental microscopy data within a multiscale simulation framework.

The work will employ Martini 3 coarse-grained (CG) simulations adapted for IDPs, complemented by an extended GōMartini 3 model that enables controlled stabilization of sequence-specific secondary structure. The researcher will investigate conformational rearrangements of individual protein chains, the nucleation of ordered β-strand–rich assemblies, and their spatial organization within biomolecular condensates, with microscopy data driving model parametrization and validation to illuminate early aggregation pathways linked to neurodegeneration.

In addition to research activities, the selected candidate will prepare scientific manuscripts, present results at international conferences, and contribute to supervision and mentoring of PhD students. The position offers an opportunity to collaborate with experts in computational biophysics, molecular modeling, and structural biology, contributing to cutting-edge research at the interface of phase separation, protein aggregation, and neurodegeneration.

Position Details

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Interested? Contact us at apoma@ippt.pan.pl