In Poma's Lab we are mostly focused on the development of novel computational strategies for the study of complex systems of biological source, exploring at the nanoscale the relationship between single molecular motion and the appearance of collective properties. For instance, the change of the biomechanical properties of large protein assemblies under new physiological conditions. The group employs a combination of different theoretical tools and multiscale simulations to bridge the gap between length and time scales in the macromolecular system. Furthermore, the team is part of the TaskForce Martini open community and works toward a versatile GōMartini model for describing large conformational changes in biomolecular complexes. Our approach has been validated by all-atom MD simulations and recently by SMFS.