My research focus on the development of multiscale approaches for biophysical systems from the modelling of single protein to their large assemblies with emphasis on human diseases (e.g. neurodegenerative) and recently in COVID-19. Our group has introduced in 2017 the Gō-MARTINI model that is able to capture large conformational changes in proteins and it has been used to emplore the nanomechanics of protein complexes. This approach has been validated by all-atom MS simulations and in collaboration with single-molecule force spectroscopy leading groups in Europe our methodology can be extended to quantified molecular interactions that drives biological processes (e.g., receptor-cell interaction).

Dr. Adolfo B. Poma

Dr. Adolfo B. Poma